AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
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Design and synthesis of isoxazolidine core-based selective COX-2 inhibitors: in vitro inhibitor activity and in silico modeling
A novel series of tricyclic isoxazolidine–imidazole derivatives (3a–l) bearing diverse substituted phenyl groups were rationally designed, synthesized, and evaluated as selective cyclooxygenase-2 (COX-2) inhibitors. The target compounds were efficiently obtained via regio- and diastereoselective 1,3-dipolar cycloadditi...