Author

M. Geddes

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Open access Sep 2026

Cusatuzumab combined with venetoclax with or without azacitidine in unfit patients with newly diagnosed acute myeloid leukemia: phase Ib ELEVATE study.

Cusatuzumab is a monoclonal antibody that binds with high affinity to CD70, a cell surface protein overexpressed on CD34+ acute myeloid leukemia (AML) progenitors and leukemia stem cells. This phase Ib study assessed the safety, tolerability and efficacy of adding cusatuzumab to standard-of-care azacitidine and venetoc...

G. Roboz, Thomas Pabst, A. Aribi et al. · Haematologica · 1 citation

Open access Jul 2026

Double-Negative T Cells Induce Ferroptosis-Dependent, MHC-Independent Cytotoxicity of CD8+ T Cells Against AML 2256323

Acute myeloid leukemia (AML) is a blood cancer originating from myeloid cells in the bone marrow with poor prognosis. CD3+CD4-CD8-double negative T cells (DNTs) is a rare subset of immune cells that have shown strong anti-AML properties. Our previous work demonstrated that allogeneic DNTs from healthy donors effe...

Jongbok Lee, Leanne Palichuk, Enoch Tin et al. · Journal of Immunology · 0 citations

Open access Jul 2026

CD4-Targeted CAR-Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia 2224687

In vivo, CAR4-DNT achieved durable leukemia clearance and prolonged survival, whereas PBS-treated mice rapidly progressed and UT-DNT recipients showed transient disease control before relapse, establishing CAR4-DNTs as a promising immunotherapy candidate for AML, supporting their further preclinical and translational d...

Shanshan Wang, Michele Nawata, Juan Arteaga et al. · Journal of Immunology · 0 citations