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M. Gómez-Galán

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Open access Sep 2026

555. Targeting kynurenine aminotransferase III: discovery of a selective and brain-penetrant inhibitor for reducing synthesis of immune-induced kynurenic acid

Abstract Background Kynurenic acid (KYNA) is a neuroactive metabolite produced via the kynurenine pathway. It acts as an endogenous N-methyl-D-aspartic acid (NMDA) receptor antagonist and is proposed to antagonize the α7-nicotinic acetylcholine receptor (α7nAChR). Elevated KYNA levels are observed in several conditions...

P. Fridh, Y. Gravenfors, L. Schwieler et al. · 0 citations

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