Heart failure with preserved ejection fraction (HFpEF) is characterised by diastolic dysfunction and impaired mitochondrial oxidative phosphorylation. Unlike heart failure with reduced ejection fraction, adaptive ketone utilisation appears limited in HFpEF, suggesting the presence of metabolic bottlenecks....
S. Kedziora, S. Geisberger, O. Popp et al.· European Heart Journal· 0 citations
Introduction Heart failure with preserved ejection fraction (HFpEF) presents a major health burden worldwide. Up to 40% of HFpEF patients present with elevated urine-albumin-creatinine-ratio levels (UACR). In this subgroup, the risk for adverse cardiovascular (CV) outcomes is increased. Prior studies suggest a correlat...
A. Kind, D. Zurkan, A. M. Chitroceanu et al.· CardioRenal Medicine· 0 citations
BACKGROUND
Pathogenic variants in RBM20 cause severe dilated cardiomyopathy. Loss-of-function variants disrupt splicing; neomorphic gain-of-function (GoF) variants also mislocalize RBM20 to cytoplasmic ribonucleoprotein granules and are associated with more aggressive disease. The mechanism by which RBM20 mislocalizati...
Julia Kornienko, Linda H. Müller, A. Nickel et al.· Circulation· 0 citations
The data indicate that pathogenic E-rich domain variants reduce RBM20 protein abundance, but that their mechanism is unlikely to be explained by haploinsufficiency alone.
Bai Fang, Kaiser Chua, Daniel Y. Li et al.· bioRxiv· 0 citations
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