Author

M. Grander

2 papers indexed here

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Sep 2026

The Iron Chaperone PCBP2 Controls Systemic Iron Homeostasis by Regulating Iron Flux in Red Pulp Macrophages.

Systemic iron homeostasis critically depends on macrophages for the recycling of iron from senescent erythrocytes. The iron chaperone poly(rC)-binding protein 2 (PCBP2) is considered to direct intracellular iron trafficking. However, its specific role in macrophage-mediated iron redistribution remains unclear. We show...

M. Grander, Lukas Mueller, M. Trebo et al. · Blood · 0 citations

Open access Oct 2026

Macrophage-specific LAMTOR2 deletion disrupts systemic iron homeostasis in mice.

It is demonstrated that LAMTOR2-dependent endosomal trafficking is a critical, previously unrecognized mechanism that stabilizes the transferrin receptor, enables essential iron recycling in macrophages and ultimately sustains systemic iron homeostasis.

Laura Homs Pérez, I. Portnaia, Markus Seifert et al. · Haematologica · 0 citations