M. Heinricher

Glucocorticoid–endocannabinoid crosstalk in the ventrolateral periaqueductal gray (vlPAG) promotes pain resolution

Inflammation is a primary response to injury. Here we show that inflammation plays a critical role in engaging the endocannabinoid system in the ventrolateral periaqueductal gray (vlPAG) to activate the descending pain modulatory circuit to inhibit pain. Inflammation-induced increases in corticosterone activate glucoco...