The surgical margin is the primary site of glioblastoma recurrence, yet its molecular features remain poorly characterized. We performed histology-guided sampling and single-cell spatial transcriptomics of surgical margin and adjacent recurrent tumor regions, with matched primary tumors from 40 patients. The surgical m...
S. Artzi, D. Harwood, A. Locallo et al.· Cancer Discovery· 0 citations
Despite recent advances in RAS-directed therapy, pancreatic ductal adenocarcinoma (PDAC) remains highly lethal. Surgical resection, chemotherapy, and radiotherapy continue to anchor treatment, but therapeutic resistance is pervasive, and most patients succumb to treatment-refractory residual disease. Advances in sing...
D. Olgun, Beatrice Awasthi, N. Lester et al.· Cancer Research· 0 citations
G-quadruplexes (G4s) are alternative DNA structures with diverse biological roles, but their examination in highly repetitive parts of the human genome has been hindered by the lack of reliable sequencing technologies. Recent long-read based genome assemblies have enabled their characterization in previously inac...
Nikol Chantzi, Shi Wei. Liew, Aurell Wijaya et al.· Genome Biology· 0 citations
Motivation Single-cell RNA sequencing (scRNA-seq) has become an attractive tool for studying complex diseases, in which transient cell states affecting diverse cell populations characterise disease development and progression. However, due to data sparsity and disease heterogeneity analysis is often challenging. With r...
Guilherme Pocas, Muhammad Umar, Oliver Davis et al.· bioRxiv· 0 citations
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