Deletion of ppe27 in Mycobacterium bovis BCG augments macrophage immune responses during infection
ABSTRACT Mycobacterial infection induces dynamic transcriptional changes in both the host and pathogen. In slow-growing mycobacteria, the ESX-5 secretion system plays a crucial role in virulence by exporting Pro–Glu (PE) and Pro–Pro–Glu (PPE) proteins, which modulate host immune responses and contribute to pathogenesis...