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Author

M. Hussein

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Oct 2026

Amygdalin (Vitamin B17) as a Natural Bioactive Compound Attenuates Polycystic Ovary Syndrome through Modulation of PPAR-γ/SREBP-1c Gene Expression: A Comparative Preclinical Study with Metformin

Polycystic Ovary Syndrome (PCOS) affects 8-13% of reproductive- age women worldwide and is characterized by metabolic, hormonal, and oxidative stress disturbances. Current therapies such as metformin provide symptomatic relief but do not address the multifactorial pathophysiology. This study aimed to evaluate the t...

Amany M. Ghazal, M. Hussein, A. F. et al. · 0 citations
Sep 2026

Integrated Experimental and Computational Evaluation of Silymarin Nanoparticles: Apoptosis Induction, EMT Reversal, and Cell Cycle Arrest in A431 Epidermoid Carcinoma Cells

Cancer remains a major global health challenge. Silymarin-based nanoparticles offer a promising, safer platform for next-generation anticancer therapies. The present study was designed to investigate the cytotoxic and apoptotic potential of silymarin nanoparticles (Sil-NPs) in A431 epidermoid carcinoma cells and to...

Enas Abdallah Elsayed, M. Hussein, A. Fayed et al. · 0 citations
Jul 2026

Innovative Anti-Obesity Strategy: Moringa peregrina Seed Extract-Stabilized Selenium Nanoparticles for Comprehensive Metabolic Health Improvement

The obesity epidemic poses a global challenge that requires safer, natural- based therapeutic alternatives. Here, we present a nanobiotechnology strategy by employing Moringa peregrina (MP) seed extract for the energy-efficient synthesis of stabilized selenium nanoparticles (MPS-SeNPs) and demonstrate their anti-ob...

Tarek Fekry, Hala O Ramadan, M. Hussein et al. · 0 citations
Aug 2026

Boswellic Acid-Nanoparticles (BA-NPs) Confer Synergistic Hepatoprotection against Paracetamol-Induced Toxicity via Attenuation of Oxidative Stress, Inflammation, and Apoptosis

Results indicate that BA- NPs prepared by Span 60/Tween 80 emulsification provide potent hepatoprotection against paracetamol- induced liver injury through synergistic, multi- mechanistic action, significantly protecting against hepatic injury by concurrently suppressing oxidative stress, inflammatory signaling pathway...

Ola Abdallah Ahmed, M. Hussein, Azza Mahmoud Abdullah · 0 citations
Jul 2026

Green-synthesized Salvia officinalis-conjugated Selenium Nanoparticles Mitigate Diabetic Complications via Multi-target Molecular and Histopathological Restoration in STZ-induced Mice

The results of this study showed that the SeNPs synthesized by SOLE extract have notable antidiabetic and antioxidant activities, which implies a combination of selenium bioactivity and some other phytochemical compounds in S. officinalis.

M. Mansour, M. Hussein, N. Mostafa et al. · 0 citations
Jul 2026

Lapachol Nanoparticles Mitigate Mercuric Chloride-induced Pulmonary Toxicity via Modulation of Oxidative Stress, Inflammatory Signaling, and Nrf2/P39 Pathways

LaP-NPs efficiently prevent HgClⁿ-induced lung injury by inhibiting oxidative stress, modulating stress-related genes, and reducing inflammatory pathways, suggesting that LaP-NPs could serve as a nanotherapeutic for heavy metal-induced pulmonary toxicity.

Azza M. Metwaly, Manar Eldeeb, M. Hussein et al. · 0 citations

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