M. I. Siddiqi

β-Sheet Antimicrobial and Antimycobacterial Peptides with a High Therapeutic Index by Employing the Repeats of a 5-Mer Segment of α-Helical Cytolytic Melittin.

MLT-2 and MLT-3 showed appreciable in vivo efficacy against Escherichia coli American Type Culture Collection 25922-infection in mice in the intravenous route and inhibited transcription/translation in in vitro assays suggesting their intracellular mode of action.

Genome-wide DNA methylation landscapes in gallbladder carcinoma: revealing shared and distinct epigenetic signatures across subtypes.

BACKGROUND Gallbladder cancer is an aggressive malignancy with poor survival rates, there are biologically distinct subtypes, yet genome-wide epigenetic differences remain poorly understood. This study was designed as an exploratory investigation of subtype-specific DNA methylation patterns. METHODS The study include...

Identification of Novel Inhibitors of JEV RdRp as Potent Antiviral Drugs: Targeting NS5-NS3 Protein Interaction

Integrated machine learning and structural bioinformatics guided identification of novel molecular scaffolds as renin inhibitors.

This study identified 4 promising hits - HTS00804, HTS05294, BTB13902, and RJC01726 with diverse piperazine and piperidine-substituted scaffolds for renin inhibition, and can be explored as a starting scaffold for further structural optimization through medicinal chemistry efforts to design next-generation direct renin...