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Early phase clinical trials are pivotal to advance development of new anticancer drugs. During this phase, the toxicity profile of the new drug and the optimal dose and dosing scheme for further clinical development are assessed. Innovation carries ethical implications, as patients included in these early phase trials...
Abstract Introduction Early-phase oncology clinical trials are often underrepresented in studies regarding publication of trial results. This study investigated the publication status of early-phase clinical trials, focusing on trials of compounds discontinued in clinical development. Methods Two retrospective cohorts...
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