BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF COMPOUND-9(O) USING LIQUID CHROMATOGRAPHY–TANDEM MASS SPECTROMETRY AND ITS APPLICATION TO A PHARMACOKINETIC STUDY
Objectives: A sensitive, specific, robust, and reliable liquid chromatography–tandem mass spectrometry (LC-MS/MS) method was developed and validated in mouse plasma for a novel Secretory Phospholipase A2(SPLA2) Inhibitor, compound-9(O), and followed by its application to a Pharmacokinetic (PK) study. Methods: A sensiti...