In situ ROPISA synthetic strategy for a β-sheet polypeptide nanoformulation and in vivo biodistribution studies.
Polypeptides are protein-like synthetic macromolecules that often require tedious post-polymerization self-assembly to encapsulate drugs or genes. Developing nanotechnology platforms for the on-demand loading of cargoes during synthesis in water would yield directly injectable nanoformulations for immediate healthcare...