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These findings establish open System One models as a promising zero shot baseline for medical AI, combining competitive predictive performance with low computational cost and efficient local calibration, and introduce a lightweight, two parameter recalibration method.
The heritability of epigenetic sites around SAT adipocyte marker genes is enriched for abdominal obesity, and that these cell-type markers are also enriched for central pathways of adipocyte function, indicating widespread cell-type level cis-type level trans effects on highly common CMDs.
Efficient multi-eNvironmental Gene-environment Interaction iNference Estimator (ENGINE), a supervised variance-component framework that learns an embedding that combines multiple environmental exposures while jointly estimating additive, G×E, and heteroskedastic noise components, making polygenic G×E analysis tractable...
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