Author

M. Jolly

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Open access Aug 2026

Regulatory stochasticity drives opposing phenotypic outcomes in cell-fate decision networks

Models of gene regulatory networks (GRNs) underlying cell-fate decision systems treat regulatory parameters as fixed quantities, although transcription-factor efficacy varies with molecular context. We asked how temporal fluctuations in interaction strength, rather than molecular abundance, alter phenotype occupancy in...

K. Hari, Abhay Gupta, Lakshmi Malvadi Shivakumar et al. · bioRxiv · 0 citations

Open access Sep 2026

Endosomal pH Triggers Amyloid β Oligomerization and Maladaptive Phenotypic Plasticity in Alzheimer’s Disease

Endosomal dysfunction is a presymptomatic hallmark of neurodegeneration. Recent evidence highlights dysregulation of endosomal pH as a central pathogenic hub in Alzheimer’s disease (AD); however, the mechanisms linking pH shifts to neurodegeneration remain incompletely defined. Here, we use a quantitative model of endo...

R. K. Meena, A. S. Duddu, M. Jolly et al. · bioRxiv · 0 citations