Genetic insights into multiple sclerosis: exploring mitochondrial DNA and nuclear POLG gene variation in a Polish single-center RRMS cohort.
AIM OF THE STUDY To evaluate the contribution of mitochondrial DNA (mtDNA) variation and four POLG mutations to disease susceptibility and course in Polish patients with relapsing-remitting multiple sclerosis (RRMS). CLINICAL RATIONALE FOR THE STUDY Mitochondrial dysfunction is increasingly implicated in the pathogen...