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Author

M. Keshavan

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Open access Sep 2026

CSenescence-associated-secretory phenotype proteins and inflammatory pathways are involved in psychosis: A transdiagnostic study using the Human Connectome Project for early psychosis (HCP-EP) data.

Biofluid proteins are promising transdiagnostic markers for delineating disease heterogeneity in psychosis. This study examined proteomic profiles in a transdiagnostic early psychosis sample to test the hypothesis that psychosis is associated with proteomic signatures of premature aging. We analyzed proteomic data from...

J. Seitz-Holland, M. Haaf, A. Mendes-Silva et al. · 0 citations
Sep 2026

Epigenetic C-reactive protein and corticolimbic gray matter volume in youth at clinical high risk for psychosis.

AIMS Inflammation and structural brain alterations are implicated in psychosis risk, yet it remains unknown whether epigenetic C-reactive protein (CRP), a DNA methylation-based estimator of cumulative inflammatory burden, is associated with brain structure in youth at clinical high risk for psychosis (CHR-P). METHODS...

B. Ku, Ying Xu, David R. Goldsmith et al. · 0 citations
Open access Sep 2026

Cerebral perfusion alterations are associated with clinical phenotypes and biotypes across the psychosis spectrum

Abstract Background Cerebral perfusion abnormalities may contribute to the pathophysiology of psychosis spectrum disorders (PSD), including schizophrenia (SZ), schizoaffective disorder (SAD), and bipolar disorder with psychotic features (BP), yet large-scale investigations remain limited. Methods Pseudo-continuous arte...

Ho-Ang Dung, V. Zeng, Jothini Sritharan et al. · 0 citations
Open access Sep 2026

Unraveling Suicidal Ideation and Behaviors in a Global Cohort of Individuals at Clinical High-Risk for Psychosis: Multivariable Correlates and Subthreshold Psychotic Symptoms.

SIB in CHR-P individuals reflects a multidimensional clinical profile primarily outside of core psychosis-risk symptoms, and overall subthreshold psychotic symptoms across the SIB spectrum indicate increasing overall subthreshold psychotic symptoms across the SIB spectrum.

S. Damiani, M. Orlandi, U. Provenzani et al. · 0 citations
Open access Jul 2026

Relationship among Sleep Disturbance, Stress, and Suicidal Ideation in Clinical High Risk for Psychosis

A relationship between sleep disturbance and suicidal ideation/attempts in CHR is supported, with participants who had lifetime ideation and attempts experiencing more sleep disturbance than those with no ideation or attempts.

H. Wastler, Aubrey M. Moe, Alexandra M Blouin et al. · 0 citations
Review Jul 2026

Toward a Pluralistic Model for the Schizophrenia Spectrum-Dopamine and Beyond.

Dopaminergic hyperactivity may be a key mechanism for core psychotic symptoms in many patients, but it is unlikely that dopamine dysregulation is a universal final common pathway across symptom domains.

M. Keshavan, Henry A. Nasrallah, A. Abi-Dargham et al. · 0 citations
Open access Aug 2026

Right hippocampal volume and attenuated psychotic symptoms distinguish subgroups of youth with common patterns of temporoparietal effective connectivity

Associations between patterns of brain connectivity and brain structural features have transdiagnostic relevance to psychopathology. There is considerable evidence for disruptions to the hippocampus and temporoparietal brain systems in psychotic disorders. The present study examines structure–function relationships—spe...

K. Aberizk, B. Ku, Heng-Yi Cao et al. · 0 citations

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