Author

M. Kikuchi

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Preprint Aug 2026

Funnel-like protein energy landscapes emerge from functional evolution under thermal fluctuations

This lattice protein model defines fitness as the equilibrium probability of a fixed active-site motif and uses multicanonical sequence sampling to show how thermal fluctuations turn a local functional requirement into a global structural constraint.

Norifumi Maruyama, M. Kikuchi · 0 citations