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A new propargyl-functionalized 2,6-bis(benzimidazolyl)pyridine-based N3-donor ligand (L) and its copper(II) complex [Cu(L)(NO3)2] have been synthesized and characterized. The ligand was designed to provide a rigid tridentate coordination environment while incorporating a propargyl moiety to modulate its electronic prop...
The results highlight that modulation of para-substituents critically influences DNA interaction, lipophilicity, mitochondrial targeting, and anticancer activity.
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