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It is found that STDP and desynchronization form a regulatory loop, in which STDP regulates the level of synchrony, and synchrony regulates subsequent learning strength, and STDP is capable of switching neurons from synchronization to desynchronization.
The feasibility of consumer-grade smartwatches as accessible platforms for deploying robust BP estimation algorithms is highlighted, though clinical reliability will require larger, more diverse populations and additional sensing modalities.
The findings suggest that quasi-evoked inhibition is a potential biomarker of tremor reduction by means of network inhibition, and the more posterior regions of the Vim may allow for better recruitment of inhibition, which may be useful for closed-loop stimulation design.
The effects of stimulation are dependent on the baseline state of the network, with the level of beta suppression dependent on the level of inhibition and the external drive, and networks with higher inhibition and lower drive show greater disruption of beta oscillations.
A comprehensive phenomenological computational model is proposed that accounts for the impact of electrical stimulation parameters on neuronal circuits while incorporating experimentally-validated synaptic and cellular constraints and provides a mechanistic framework for understanding DBS representation and propagation...
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