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Review Open access Oct 2026

Inherited platelet function disorders: a comprehensive narrative review focusing on diagnostic and management aspects

Qualitative and quantitative inherited platelet disorders (IPDs) are a heterogeneous group of rare bleeding conditions caused by inherited variants in genes that affect platelet production and function. Clinically, IPDs are characterized by significant phenotypic heterogeneity, ranging from mild mucocutaneous bleeding...

Antonietta Ferretti, Nicola Portesi, Chiara Gorio et al. · 0 citations
Open access Oct 2026

CO-78 | REAL-WORLD MANAGEMENT OF ACQUIRED HEMOPHILIA A: FOCUS ON RECOMBINANT PORCINE FVIII AS FIRST-LINE HEMOSTATIC TREATMENT AND LONG-TERM OUTCOMES

Background. Acquired Hemophilia A (AHFA) is a rare bleeding disorder caused by the development of neutralizing autoantibodies against endogenous coagulation factor VIII (FVIII). The clinical presentation is often characterized by sudden, severe subcutaneous and mucosal hemorrhages. Management is inherently complex: it...

M. Leotta · 0 citations
Open access Oct 2026

CO-75 | ASSAY DISCREPANCY IN HEMOPHILIA A CARRIERS: CLINICAL AND GENETIC INSIGHTS

Dependence on the One-Stage Assay (OSA) alone offers an incomplete assessment of the hemostatic profile in carriers, and the observed OSA/CSA divergence represents a distinct biological phenomenon rooted in altered protein kinetics.

M. Leotta · 0 citations

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