Author

M. López

2 papers indexed here

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Open access Aug 2026

Antibody Recognition and Functional Activity Against a Conserved Trypanosoma cruzi Peptide and Its Natural Variants in Kinetoplastids

The TcTLE peptide (TLEEFSAKL), located at the amino-terminus of the Trypanosoma cruzi Kinetoplastid Membrane Protein-11 (KMP-11), induces robust humoral and cellular immune responses, suggesting its potential for serological diagnostics or immunoprophylaxis. However, natural variants of this sequence exist in Leishmani...

J. Zuluaga, F. Gúzman, J. C. Santos-Barbosa et al. · Acta Parasitologica · 0 citations

Sep 2026

Efficacy and safety of alternative benznidazole and nifurtimox regimens for adults with chronic Trypanosoma cruzi infection (TESEO): an open-label, randomised, non-inferiority phase 2b trial.

BACKGROUND Trypanosoma cruzi infection affects over seven million people worldwide. Standard-of-care benznidazole or nifurtimox causes drug-related adverse events leading to definitive treatment interruption. We evaluated whether shortened, extended, or halved-dose regimens preserve efficacy and improve tolerability....

Cristina Alonso-Vega, Jimy José Pinto Rocha, Licet Gimena Rojas Delgadillo et al. · Lancet. Infectious Diseases... · 0 citations