Author

M. M. Desai

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Open access Sep 2026

Interactions between epistasis and pleiotropy in generic models of complex traits

Evolution in fluctuating environments depends critically on epistatic interactions between mutations and the pleiotropic effects these mutations have on fitness across multiple conditions. However, while these effects of epistasis and pleiotropy have been extensively studied individually, the interactions between them...

Caelan Brooks, Misha Gupta, Gautam Reddy et al. · bioRxiv · 0 citations

Sep 2026

On inferring epistatic complexity in protein sequence-function landscapes.

The extent to which epistatic interactions create complexity in protein sequence-function landscapes is highly contested. Numerous empirical studies have found evidence for complex landscapes with widespread high-order epistasis. However, recent work has argued that many of these empirical sequence-function landscapes...

Thomas Dupic, Angela M. Phillips, M. M. Desai · Genetics · 0 citations

Open access Oct 2026

Mutation choice biases the structure of empirical fitness landscapes

Evolution can be thought of as taking place in a fitness landscape which maps each genotype to a fitness value. This abstraction has motivated significant efforts to quantify the statistical properties of random fitness landscapes with different amounts and types of interactions among loci—broadly referred to as epista...

Caelan Brooks, M. M. Desai, Maryn O. Carlson · bioRxiv · 0 citations