Author

M. Matthay

2 papers indexed here

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Open access Aug 2026

Plasma proteomics defines two reproducible subphenotypes of sepsis-associated acute kidney injury with distinct outcomes

Sepsis is the leading cause of acute kidney injury in critically ill patients, and this complication carries a high risk of death. The biology underlying it varies between patients, which may explain why treatments have not succeeded. Here we show, using an ensemble method that groups patients by patterns across hundre...

M. Legrand, H. Nguyen, C. Calfee et al. · Nature Communications · 0 citations

Open access Sep 2026

GDF15 as a biomarker of metabolic dysfunction and mortality in sepsis and ARDS: a cohort study

Two inflammatory phenotypes of sepsis and ARDS, hyperinflammatory and hypoinflammatory, have consistently been described with distinct biology and clinical outcomes. Mitochondrial metabolic dysfunction has been identified as a key characteristic of the Hyperinflammatory phenotype. Growth differentiation factor-15...

N. Alipanah-Lechner, Carolyn Leroux, A. Ringor et al. · Critical Care · 0 citations