CTLA-4 as a Double-Edged Sword in Colorectal Cancer: Molecular Insights into Immune Checkpoint Suppression and Therapeutic Targeting.
Colorectal cancer (CRC) remains a major global health burden and ranks third among the most commonly diagnosed malignancies and the second leading cause of cancer-related mortality worldwide. Its development arises through successive molecular and cellular alterations driven by cumulative genetic mutations, environment...