This study mapped whole-brain connectivity of the locus coeruleus (LC) across aging and the Alzheimer’s disease (AD) continuum and introduced a novel imaging marker called the LC gap, which quantifies deviations in LC connectivity patterns. Among several LC gap measures, left-right asymmetry was the most informative: i...
Blanca Zufiria, D. Veréb, M. Mijalkov et al.· Emerging Topics in Artificia...· 0 citations
Cognitive performance declines with aging, yet current assessment tools such as neuropsychological testing and task-based fMRI face limitations including variability, learning effects, and limited standardization. Here, we introduce in-silico cognition, a reservoir computing framework that models cognitive task perform...
M. Mijalkov, Jia-Wei Sun, Yu-Wei Chang et al.· Emerging Topics in Artificia...· 0 citations
Parkinson’s disease (PD) is a heterogeneous disorder with distinct phenotypes that may emerge years before motor diagnosis. We investigated the proposed “body-first” and “brain-first” PD phenotypes across prodromal and clinical stages using longitudinal clinical, imaging, and genetic data from 2,030 participants in the...
M. Passaretti, D. Veréb, M. Mijalkov et al.· Emerging Topics in Artificia...· 0 citations
A dual-gradient architecture is revealed that reflects the functional heterogeneity of the SN and offers new markers, grounded in behaviour and pathology, for stratifying neurodegenerative disease risk in aging, PD and AD.
D. Veréb, Blanca Zufiria-Gerbolés, M. Passaretti et al.· Molecular Psychiatry· 0 citations
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