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Aug 2026

Administration of Preoperative Cryoneurolysis is Associated with Continued and Persistent Opioid Reduction and Improved Outcomes in Primary Total Knee Arthroplasty.

BACKGROUND Cryoneurolysis, a percutaneous technique applying targeted cold therapy to sensory nerves, has emerged as a non-opioid adjunct that may provide sustained analgesia after total knee arthroplasty (TKA). This study aimed to (1) determine whether preoperative cryoneurolysis reduces postoperative opioid use, (2)...

Mitchell K. Ng, Jennifer H. Lin, Andrew I. Spitzer et al. · 0 citations
Review Sep 2026

Periarticular Injection Cocktails for Pain Management After Total Knee Arthroplasty: A Systematic Review of Randomized Controlled Trials.

Multimodal PAI improves early postoperative outcomes after TKA, especially versus placebo, and the LB is a promising component, with some studies showing better pain control, lower opioid use, and higher patient satisfaction.

Mitchell K. Ng, Leonidas E. Mastrokostas, P. Mastrokostas et al. · 0 citations

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