Author

M. Muzumdar

2 papers indexed here

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Sep 2026

Abstract B059: Loss of Cullin-RING Ligase 5 mediates resistance to RAS inhibition in pancreatic cancer

The proto-oncogene KRAS is mutated in greater than 90% of pancreatic ductal adenocarcinoma (PDAC). Although newly developed multi-RAS(ON) inhibitors (daraxonrasib) have significantly improved progression-free and overall survival compared with current standard-of-care chemotherapy in PDAC patients, both clinical and...

Cassandra S. Markham, Ilze M. Olivi Gomes, Yi Di et al. · Cancer Research · 0 citations

Open access Sep 2026

Baseline cellular state shapes the molecular impact of mutant KRAS alleles in reconstituted pancreatic cancer cells.

KRAS is mutated in over 90% of pancreatic ductal adenocarcinomas (PDAC), where hotspot alterations in codons 12, 13, and 61 drive tumor initiation and progression. Although distinct biochemical properties have been described for individual KRAS mutants, whether they generate unique allele-specific signaling programs in...

Yanixa Quiñones-Avilés, Barbora Šalovská, Cassandra S. Markham et al. · Molecular Omics · 0 citations