Open access
Aug 2026
Emergence of mutHV76G in carbapenem-resistant Klebsiella pneumoniae disrupts DNA mismatch repair and results in a hypermutator phenotype
ABSTRACT Hypermutation-driven evolution is a major contributor to antibiotic resistance in some bacterial pathogens, but its role in Klebsiella pneumoniae remains poorly defined. We analyzed 11 KPC-producing ST258 K. pneumoniae isolates collected serially over ~4 years from a host with persistent colonization and recur...
Shao-Ji Cheng, Cornelius J. Clancy, G. Fleres et al.
· Antimicrobial Agents and Che... · 0 citations