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Open access Jul 2026

The Evolution, Landscape, and Clinical Tradeoffs of In Vivo CAR-T Therapy

Chimeric antigen receptor (CAR)-T cell therapy has revolutionized hematological oncology, yet conventional ex vivo manufacturing imposes severe clinical and economic burdens. In vivo CAR-T therapy—programming endogenous T cells via systemic vector delivery—has emerged to overcome these limitations. This communication a...

M. Ni · 0 citations

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