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Author

M. Novelli

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Open access Sep 2026

Adaptive design strategies for ethical and efficient clinical trials using simulated annealing.

We introduce a flexible adaptive design strategy for treatment allocation in clinical trials based on a randomized simulated annealing algorithm. The proposed approach provides a unified and modular framework for implementing a broad range of adaptive randomization objectives, including covariate-adaptive (CA), respons...

Rosamarie Frieri, Francesco Mariani, M. Novelli · 0 citations

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