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M. O. Din

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Open access Sep 2026

Genome-resolved ecology and evolution of the microbiome enabled by quantitative long-read metagenomics

Standard metagenomics resolves microbial communities only in relative terms and at coarse taxonomic resolution, obscuring how individual strains change in absolute abundance and evolve within a host1–6. We present long-read quantiomics (LRQ), a quantitative metagenomics platform coupling long-read sequencing with plasm...

M. O. Din, C. Brennan, Jian-Shu Zhao et al. · 0 citations
Open access Aug 2026

Canalesolide A, a Structurally Unique Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania sp. with Potent Antitrypanosomal Activity

Canalesolide A displays potent, low nanomolar antitrypanosomal activity against human-infective subspecies of T. brucei with rapid elimination of parasites within 1 h at 1 μM, and preliminary in vivo efficacy/toxicity studies in infected mice suggest a narrow therapeutic window highlighting the need for improved select...

Thaiz R. Teixeira, Byeol Ryu, Richard Cox et al. · 0 citations

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