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Author

M. Okoshi

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Open access Oct 2026

HER2 CAR-expressing iPSC-derived iNKT cells exhibit multifaceted immunomodulatory functions beyond direct tumor killing

It is demonstrated that HER2 CAR-ipsNKT cells not only exert direct antitumor activity but also promote CD11c-dependent expansion of antigen-reactive CD8+ T cells, suggesting their capacity to induce broader antitumor immunity.

Koichiro Shioya, Tomio Matsumura, Akane Urakami et al. · 0 citations
Open access Jul 2026

Extending the residence period of allogeneic iPSC-derived invariant natural killer T cells in humanized mice by editing HLA class I expression

An approach to extend the residence time of iPSC-derived invariant natural killer T (iPSC-derived iNKT) cells in humanized mice by genetically modifying HLA class I expression is presented, with the potential to develop universal off-the-shelf immunotherapy.

Yun‐Hsuan Chang, T. Aoki, M. Okoshi et al. · 0 citations

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