Review
Open access
Oct 2026
SHP2 in Cancer: From Tumor Biology to Therapeutic Targeting.
SHP2 is a tyrosine phosphatase that mediates intracellular signaling downstream of transmembrane receptors regulated by a pair of src homology 2 (SH2) domains. Its overexpression and mutation are pivotal in driving tumor progression by influencing various cancer's fundamental characteristics, such as metastasis, DNA re...
Maryam Jama, M. Overduin, K. Barakat
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