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Sep 2026

Synthesis and Biological Evaluation of Imidazo‐Thiadiazole‐Linked Benzisoxazole Hybrids as Dual α ‐Glucosidase and α ‐Amylase Inhibitors With Antioxidant Potential

Type 2 diabetes mellitus (T2DM) remains a major global health challenge, necessitating the discovery of novel therapeutics with improved safety and efficacy. In this study, a series of imidazo‐thiadiazole‐linked benzisoxazoles ( 1–20 ) was synthesized and evaluated for dual inhibitory activity against α ‐glucos...

Mehwish Solangi, Komal Solangi, M. Özil et al. · 0 citations
Open access Aug 2026

Trifluoromethyl-Benzimidazole-Hydrazone Derivatives as Promising Selective Anticancer Agents: Synthesis, Cytotoxicity, and Molecular Docking Insights

Background/Objectives: Benzimidazole and hydrazone scaffolds are widely investigated in anticancer drug discovery because of their structural versatility and capacity to interact with multiple cancer-related targets. This study aimed to synthesize a series of trifluoromethyl-substituted benzimidazole-hydrazone derivati...

M. Özil, Eyüp Önelge, M. Emirik et al. · 0 citations

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