Homeostatic imbalance between von Willebrand factor and ADAMTS13 on hemorrhagic shock-induced endotheliopathy.
Endothelial dysfunction in patients after severe injury with hemorrhagic shock is associated with excessive release of ultralarge von Willebrand factor (VWF) without a corresponding increase in ADAMTS13 (A disintegrin and metalloprotease thrombospondin type 1 motifs, member 13), resulting in acquired ADAMTS13 deficienc...