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Author

M. Péteri

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Open access Aug 2026

USP5 acts as a proteolytic switch to control SDE2 function via UBL-directed cleavage

A non-canonical proteolytic function of USP5 is revealed, uncovering a previously unrecognised regulatory axis linking deubiquitinating enzymes to protein maturation, expanding the substrate repertoire for USP5 and providing a framework for identifying protease–substrate relationships in post-translational regulation.

Liam T. Hales, Paul M. Tammiste, Adam J. Walker et al. · 1 citation

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