Author

M. Portero-Otín

2 papers indexed here

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Open access Sep 2026

A sphingomyelin-cholesterol complex regulates TLR4 activation in microglia

Microglial activation in response to lipopolysaccharide (LPS) requires Toll-like receptor 4 (TLR4) redistribution into cholesterol- and sphingolipid-rich membrane domains, yet the lipid determinants of this process remain unclear. Here, we identify cholesterol accessibility as a key driver of TLR4-dependent microglial...

C. Antón-Barros, Beatriz Villarejo-Zori, Sara Carmona-Lorenzo et al. · bioRxiv · 0 citations

Open access Jul 2026

Antisense oligonucleotides treatment uncovers differences in the modulation of dysregulated intracellular pathways in Spinal Muscular Atrophy motoneurons.

Spinal Muscular Atrophy (SMA) is a neuromuscular genetic disorder resulting from the mutation or deletion of the Survival Motor Neuron 1 (SMN1) gene and the reduction of the Survival Motor Neuron (SMN) protein. As a result, SMN level in SMA depends on the almost identical copy gene SMN2, which produces a small amount o...

María P. Miralles, Isabel Gimenez-Fernandez, María Beltran et al. · Cell Death and Disease · 0 citations