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Open access Sep 2026

Multi-Species, Genome-Wide Metabolic Network Reconstructions Reveal the Basis for Metabolic Versatility in Mycobacteria

The genus Mycobacterium comprises over 200 species, many of which now have complete genome sequences. Some are major pathogens causing diseases like tuberculosis and leprosy, while others are harmless environmental organisms with useful abilities such as degrading pollutants. Environmental mycobacteria are often seen a...

Ignacia Cancino Aguirre, M. Priya, A. Garza-Garcia et al. · 0 citations
Open access Aug 2026

A cloaked glutamate decarboxylase sustains the GABA shunt in Mycobacterium tuberculosis

It is demonstrated that Rv2531c is a novel L-glutamate decarboxylase that sustains carbon flux through the GABA shunt in M. tuberculosis and proposes that many members of this large and diverse enzyme family catalyze distinct reactions and participate in previously unrecognized metabolic pathways, revealing a broader a...

H. M. Thai, Debbie M. Hunt, Yugen Miyahara et al. · 0 citations

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