Author

M. R. Larsen

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Open access Aug 2026

STEP-PTMs: Sequential TMT-based Enrichment and Profiling of Post-Translational Modifications

Application of STEP-PTM to TMT16-plex cerebral brain organoids enabled the quantification of 10,413 proteins, 2,969 metabolites, 19,655 phosphopeptides, 28,876 peptides containing reversibly modified cysteines, 9,723 peptides containing free cysteines, 1,716 intact sialylated N-linked glycopeptides and 771 lysine-acety...

Lucrezia Criscuolo, S. B. Elmkvist, Arkadiusz Nawrocki et al. · bioRxiv · 0 citations

Jul 2026

Stimulus-Evoked Network Dynamics in Human Cortical Organoids: From a Graph-Computational Framework to Repeated-Stimulation Depression

A graph-computational framework to quantify stimulus-evoked propagation and revealed a control-validated phenomenon, that repeated stimulation reshapes organoid networks is established, but longitudinal designs in which every preparation is stimulated cannot separate this from developmental maturation.

E. Nadimi, V. C. Gogineni, Jan-Matthias Braun et al. · arXiv.org · 0 citations

Jul 2026

Proteomic and Phosphoproteomic Characterization of Disease-Associated Alterations in Nerve Terminals and Protein Inclusions of Alzheimer's Disease Patients.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by synaptic dysfunction, protein aggregation, and widespread molecular alterations in the brain. In this study, we applied quantitative mass spectrometry-based proteomics and phosphoproteomics to characterize synaptosomes and sarkosyl-in...

S. B. Elmkvist, Camilla Thygesen, Pia Jensen et al. · Journal of Proteome Research · 0 citations