Design and synthesis of new 2-aminopyrimidine-thiazolidinone hybrids with enhanced antimicrobial activity: in-vitro evaluation and multiscale computational studies.
A series of novel 2-aminopyrimidine-thiazolidinone hybrids were designed, synthesized, and evaluated for antimicrobial activity against selected bacterial and fungal pathogens. Structural characterization was accomplished using FT-IR, NMR, and mass spectrometry. Among the synthesized compounds, SPRB21 exhibited the mos...