Deep sedation and delirium are common in COVID-19 intensive care unit (ICU) patients. Biomarkers for prediction, detection, and monitoring are missing. Unbiased omics analyses are warranted to gain a systems biology view on pathophysiology. This prospective observational satellite study analysed the proteome signatures...
A. Edel, J. Sreekanth, Florian Kurth et al.· Scientific Reports· 0 citations
The data reveals extensive proteoform diversity of the human plasma proteome, and implies that proteoform diversity represents an enormous untapped reservoir for biomedical research and biomarker discovery.
Boris Zühlke, T. Schwecke, T. Shapira et al.· bioRxiv· 0 citations
BACKGROUND AND AIMS
Individuals affected by obesity present different health trajectories and do not suffer from cardiometabolic complications all in the same way. There is a need to better understand obesity subtypes and to develop approaches for stratification. In this study we investigated metabolomic and proteomic...
G. Pontali, C. Weichenberger, Johannes Rainer et al.· NMCD. Nutrition Metabolism a...· 0 citations
It is demonstrated that serum proteomics can support rare disease diagnosis and identify disease-causing genes in patients undiagnosed after GS, although successful implementation will likely depend on tissue specificity of protein expression, detectability in blood, proteomic platform coverage, and sensitivity.
J. Carrasco-Zanini, J. Andrade, M. Pietzner et al.· Science Translational Medici...· 0 citations
This study revealed that mutations in key enzymes and transcriptional regulators at various metabolic branching points were essential for effective growth on D-xylose, enabling optimized partitioning of carbon through central metabolism despite the loss of the canonical EMP glycolytic route.
C. Iacometti, Valérie A. Delmas, Mélodie Cadillon et al.· Metabolic Engineering· 0 citations
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