Experimental results from breast, lung, gastric, liver, hematological, and melanoma models suggest that dysregulated PDK1 signaling can increase the output of the PI3K-AKT-mTOR pathway, invasion, metabolic adaptation, and resistance to specific hormonal, chemotherapeutic, and targeted therapies.
Darshana Ballagere Honnasiddappa, M. Ramar, Tincy Biju et al.· International Journal of Bio...· 0 citations
Evidence on Real-World Data (RWD) integration with Artificial Intelligence (AI) for enhanced Adverse Drug Reaction (ADR) detection, evaluates generative AI like ChatGPT-4 and LLaMA-2 in Substance Use Disorder (SUD) scenarios, discusses current applications, and outlines future directions is synthesized.
Pritam Kayal, Priya Manna, Ramit Rahaman et al.· Current pharmaceutical desig...· 0 citations
Findings support the hypothesis that ICA may serve as a valuable natural compound for treating HER2‐driven breast cancer; it requires further experimental validation.