M. Rautenbach

In silico identification of selective cyclodecapeptide inhibitors targeting Plasmodium falciparum Grp78 chaperone

This study sought to identify peptides that mimic the substrates of PfGrp78, which can be potential inhibitors of PfGrp78, and explored the mechanism of action of cyclodecapeptides, gramicidin S (GS) and tyrocidines (Trcs), which were previously shown to exhibit potent antimalarial activity.