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Review Open access Aug 2026

“Left Atrial Appendage Closure Versus Medical Therapy in Atrial Fibrillation: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials”

We aim to compare the impact of left atrial appendage closure vs. medical therapy on clinical outcomes in patients with atrial fibrillation, focusing on key clinical outcomes relevant to thromboembolic prevention. We conducted a PRISMA‐guided systematic review and meta‐analysis of studies comparing LAAC with medical th...

A. AL-Janabi, A. Al-shammari, A. Hageen et al. · 0 citations
Review Open access Sep 2026

Interpreting heart rate variability in clinical context: a framework for understanding a multidimensional autonomic biomarker

Heart rate variability (HRV) is a non-invasive marker of autonomic cardiovascular regulation that reflects beat-to-beat fluctuations in cardiac cycle length. Reduced HRV has been associated with adverse cardiovascular outcomes across multiple disease states, yet its clinical use remains limited by substantial interpret...

B. Ghazzal, Ibrahim Hasan, Nebras Hasan et al. · 0 citations

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