Poly (ADP-ribose) polymerase inhibitors (PARPi) have transformed the treatment landscape for homologous recombination-deficient (HRD) cancers, particularly those harboring BRCA1/2 mutations, including breast, ovarian, prostate, and pancreatic cancers, by exploiting the synthetic lethality induced by HR deficiency (HRD)...
Kousalya Lavudi, M. Renjith, Charan Pithana Sai Venkata Vijay et al.· International Journal of Mol...· 0 citations
Background and objectives: Long-term infection with HPV16 is the main cause of cervical cancer, and the viral E6 protein contributes by recruiting the host ligase E6AP, which marks p53 for destruction. Leaf extracts of Dioscorea transversa R. Br. have been reported to contain more polyphenols and to show stronger anti-...
K. Geetha, M. Adithya, M. Renjith et al.· Adolescência e Saúde· 0 citations
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