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M. Sadar

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Jul 2026

Abstract IA02: Direct targeting of the intrinsically disordered transactivation domain of androgen receptor enables transcriptome-selective pharmacology

Androgen receptor (AR) is a therapeutic target for prostate cancer. Despite effective drugging its folded ligand-binding domain (LBD), resistance will develop by mechanisms involving reactivation of AR signaling. These mechanisms include expression of constitutively active AR that lacks LBD such as AR-V7 which fueled...

M. Sadar · 0 citations

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