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M. Sadatsafavi

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Open access Oct 2026

ACCEPT 3.0: Recalibrating ACute COPD Exacerbation Prediction Tool (ACCEPT) for global use

The ACute COPD Exacerbation Prediction Tool (ACCEPT) is an algorithm for predicting 12-month risk of chronic obstructive pulmonary disease (COPD) exacerbations. To make it suitable for international use, we externally validated and recalibrated ACCEPT 2.0 to incorporate country-specific background exacerbation risk, us...

L. Lim, J. Mehareen, Amin Adibi et al. · 0 citations
Open access Sep 2026

Assessing the impact of earlier initiation of biologics on clinical remission and other outcomes in a global real-life severe asthma cohort from CHRONICLE, ISAR and OPCRD.

BACKGROUND Biologics are generally reserved for severe asthma (SA) after standard treatments have failed. Their recommendation is based on randomized controlled trials, designed to assess efficacy but not the optimal timing for biologic initiation. RESEARCH QUESTION Does the timing of biologic initiation affect SA ou...

G. Canonica, G. Christoff, Ming-Ju Tsai et al. · 0 citations
Preprint Sep 2026

Bayesian additive regression trees for evaluating treatment benefit predictors using observational data

A treatment benefit predictor (TBP) is an algorithm that maps a patient's characteristics to their putative benefit from a given treatment, which can be used to inform treatment decisions. However, a TBP must be evaluated in the target population before being adopted for patient care. When only observational data are a...

Yuan Xia, M. Sadatsafavi, J. Mehareen et al. · 0 citations
Review Jul 2026

Sex-specific associations between ambient air pollution exposure thresholds and lung function in middle-aged and older Canadians: an analysis of CLSA data.

BACKGROUND Ambient air pollution is associated with reduced lung function, but whether sex modifies the association with threshold-based exposures remains unclear. This cross-sectional study examined sex-specific associations between threshold-based exposures to fine particulate matter (PM2.5), nitrogen dioxide (NO2),...

Ugochukwu Odimba, J. Farrell, M. Sadatsafavi et al. · 0 citations

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