Open access
Jul 2026
Vardenafil Alleviates Doxorubicin-Induced Cardiotoxicity Associated with Restoration of the AMPK/SIRT1 Signaling Pathway
It is demonstrated that Var attenuates doxorubicin-induced cardiotoxicity, and its cardioprotective effects are associated with restoration of the p-AMPK/SIRT1/Nrf2/PPARγ signaling pathway, together with reductions in oxidative stress, apoptosis, and fibrosis.
Eman H. Yousef, M. A. El-Gammal, Muhammed M. Salahuddin et al.
· Biomedicines · 0 citations