Open access
Aug 2026
Preclinical Evaluation of Combined Polo-like Kinase 1 Inhibition and Navitoclax in Experimental Models of Lung Cancer
While PLK-1 inhibition exerts antitumor effects in certain in vivo contexts, the therapeutic synergy observed in vitro with Navitoclax does not consistently translate to in vivo lung cancer models, which highlights the challenges of translating combinatorial mitotic and apoptotic targeting strategies into effective in...
Bárbara Pinto, Mateus Prates-Rodrigues, D. A. B. Nobre et al.
· International Journal of Mol... · 0 citations